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KMID : 1134820200490080893
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 8 p.893 ~ p.899
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Hypoglycemic and Hypolipidemic Effects of HMR (Home Meal Replacement) with Nondigestible Maltodextrin in C57BL/KsJ-db/db Mice
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Ko So-Yeon
Kim Ha-Rim
Kim Seon-Young
Choi Jong-Un
Yu An-na
Yoon Ji-Young
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Abstract
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Nondigestible maltodextrin has been reported to have hypoglycemic, triglyceride, and cholesterol-lowering effects. In this study, we evaluated the effect of frozen rice containing nondigestible maltodextrin on hyperglycemia and dyslipidemia in type 2 diabetes mice model. C57BL/KsJ-db/m and db/db mice were divided into five groups; non-diabetic group (ND), diabetic mellitus group (DM), positive control group (PC, rosiglitazone), HMR-type frozen rice fed group (HFR), and HMR-type frozen rice containing nondigestible maltodextrin fed group (HFRN) for 6 weeks. Blood glucose, insulin, glycated hemoglobin (HbA1c), oral glucose tolerance test, and intraperitoneal insulin tolerance tests were analyzed. HFRN treatment significantly decreased body weight gain, levels of fasting glucose and postprandial glucose, and glucose intolerance compared with the DM group (P<0.01). Moreover, HFRN ameliorated insulin resistance with pancreatic tissues damage (P<0.01) in C57BL/KsJ-db/db mice. In addition, HFRN alleviated hepatic steatosis based on reduced liver hypertrophy and hepatic lipid accumulation. The levels of glutamic oxaloacetic transaminase (GOT; AST) and glutamic pyruvic transaminase (GPT; ALT), which are indicators of liver function, were also remarkably reduced in the HFRN group (P<0.01). Taken together, these results suggest that HMR-type frozen rice supplemented with nondigestible maltodextrin could be used as functional foods for improvement of hyperglycemia and dyslipidemia.
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KEYWORD
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nondigestible maltodextrin, HMR, hyperglycemia, dyslipidemia, db/db mice
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